https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43691 Wed 28 Sep 2022 14:35:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32520 Wed 13 Jun 2018 11:09:15 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19225 Wed 11 Apr 2018 16:44:01 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45596 Wed 02 Nov 2022 13:53:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49464 Thu 18 May 2023 14:19:57 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40169 in vitro model of the pulmonary epithelial-endothelial barrier and novel murine models to investigate the role of glycemic variability in influenza severity. In vitro, a history of glycemic variability significantly increased influenza-driven cell death and destruction of the epithelial-endothelial barrier. In vivo, influenza virus-infected mice with a history of glycemic variability lost significantly more body weight than mice with constant blood glucose levels. This increased disease severity was associated with markers of oxidative stress and hyperinflammation both in vitr and in vivo. Together, these results provide the first indication that glycemic variability may help drive the increased risk of severe influenza in people with diabetes mellitus.]]> Fri 15 Jul 2022 10:39:14 AEST ]]>